Ascorbyl Glucoside Introduction
Ascorbyl Glucoside (often abbreviated as AA-2G) is an innovative, highly stable derivative of L-Ascorbic Acid (Vitamin C). By attaching a glucose molecule to the active hydroxyl group of Vitamin C, the compound is effectively protected from premature degradation when exposed to heat, light, and oxygen. This chemical modification allows Ascorbyl Glucoside to remain stable in aqueous cosmetic formulations while retaining all the biological benefits of traditional Vitamin C once it penetrates the skin.
Upon topical application, alpha-glucosidase enzymes present in the skin gradually cleave the glucose molecule from the compound, continuously releasing pure L-Ascorbic Acid into the cellular matrix. This enzymatic sustained-release mechanism prevents the sudden oxidation spikes common with raw Vitamin C, ensuring long-lasting antioxidant protection, effective melanin inhibition, and sustained collagen synthesis without causing acute skin irritation. UET Chemical supplies premium-grade Ascorbyl Glucoside manufactured under strict process controls to ensure batch-to-batch consistency for global formulators and cosmetic brands.
| Chemical Information Attribute | Details |
| CAS Number | 129499-78-1 |
| EINECS Number | 433-260-1 |
| MDL Number | MFCD01865421 |
| IUPAC Name | (2R)-2-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl alpha-D-glucopyranoside |
| Synonyms | AA2G; 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid; Ascorbic acid 2-glucoside |
| Molecular Formula | C12H18O11 |
| Molecular Weight | 338.27 g/mol |
| Melting Point | 316 deg F to 324 deg F (158 deg C to 162 deg C) (Industry standard; subject to batch COA) |
| LogP | -2.4 (Predicted) |
| Chemical Category | Vitamin C Derivative / Glycoside / Antioxidant |
| Mechanism of Action | Competitive inhibition of tyrosinase via reduction of dopachrome; free radical scavenging; collagen stimulation via fibroblast activation |
| Natural Occurrence | Synthetic derivative (Not naturally occurring) |
Ascorbyl Glucoside Specifications
UET Chemical enforces rigorous quality control protocols for every production batch. The table below outlines our standard analytical parameters and testing methods for Ascorbyl Glucoside.
| Test Item | Specification Limits | Test Method |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Purity) | >=98.0% (calculated on dry basis) | HPLC |
| pH (1% aqueous solution) | 5.0 to 7.0 | Potentiometry |
| Specific Rotation [alpha]D20 | +105 deg to +115 deg | Polarimetry |
| Loss on Drying | <=0.5% | Gravimetric (221 deg F / 105 deg C, 2h) |
| Residue on Ignition | <=0.1% | Gravimetric |
| Heavy Metals (as Pb) | <=10 ppm | ICP-MS |
| Arsenic (As) | <=2 ppm | ICP-MS |
| Total Aerobic Microbial Count | <1000 CFU/g | Pharmacopeial Method |
| Yeast and Mold | <100 CFU/g | Pharmacopeial Method |
Available Documentation & Support Files:
- Certificate of Analysis (COA) per batch
- Material Safety Data Sheet (MSDS / SDS)
- Technical Data Sheet (TDS)
- HPLC Chromatogram and Heavy Metal Test Report
Ascorbyl Glucoside Applications
Ascorbyl Glucoside is prized in the personal care and cosmetic industry for its multi-functional efficacy in skin-brightening and anti-aging formulations.
| Application Field | Typical Use Level | Key Cosmetic Benefits |
| Skin Brightening & Whitening | 2.0% to 5.0% | Inhibits melanin synthesis by reducing dopachrome and suppressing tyrosinase activity; fades hyperpigmentation and age spots. |
| Anti-Aging & Anti-Wrinkle | 1.0% to 3.0% | Stimulates collagen production in dermal fibroblasts, improving skin elasticity and reducing fine lines. |
| Photoprotection & Antioxidant | 1.0% to 5.0% | Neutralizes UV-induced reactive oxygen species (ROS), mitigating photo-aging and cellular damage. |
Exceptional Stability: Resists discoloration and degradation when exposed to light, air, and elevated temperatures compared to pure ascorbic acid.
Skin-Friendly Profile: Neutral pH range in solution reduces irritation potential, making it suitable for sensitive skin formulations.
Synergistic Performance: Blends seamlessly with niacinamide, arbutin, and hyaluronic acid to boost overall efficacy.
Formulation Versatility: Easily incorporated into serums, essences, lotions, and anti-aging creams without disrupting emulsion stability.
Ascorbyl Glucoside Storage and Stability
Proper storage ensures the long-term chemical integrity and performance of Ascorbyl Glucoside raw material.
| Storage Parameter | Recommended Condition |
| Shelf Life | 24 months from manufacturing date in unopened original packaging |
| Temperature | Store below 77 deg F (25 deg C); protect from excessive heat and direct sunlight |
| Humidity | Relative humidity below 65% |
| Light Protection | Keep container tightly sealed in a dark, dry, and well-ventilated warehouse |
- Hygroscopic Nature: The powder readily absorbs moisture from the ambient air. Always reseal aluminum foil bags or fiber drums immediately after dispensing.
- In-Process Handling: Dissolve in water phase at temperatures below 122°F (50°C) during formulation to prevent thermal stress.
- Container Integrity: Store exclusively in original packaging equipped with food/cosmetic-grade polyethylene liners.
Ascorbyl Glucoside Usage Guide
Incorporating Ascorbyl Glucoside into finished cosmetic emulsions requires precise formulation steps to maximize its enzymatic conversion efficacy on the skin.
- Phase Separation: Prepare the water phase using deionized water, ensuring water temperature does not exceed 122°F (50°C).
- Dissolution: Slowly add Ascorbyl Glucoside powder into the water phase under continuous mechanical stirring until completely dissolved and clear.
- pH Adjustment: Adjust the pH of the aqueous solution or final emulsion to between 5.0 and 7.0 using a suitable buffer (such as sodium citrate/citric acid) to optimize both stability and enzymatic cleavage.
- Cool Down & Emulsification: Combine with oil phases or other active ingredients during the cool-down stage (below 104°F/40°C) if formulating complex emulsions.
| Ingredient Compatibility | Classification | Formulatory Note |
|---|---|---|
| Water / Glycerin / Hyaluronic Acid | Compatible | Excellent co-solvents and moisture-binding agents. |
| Niacinamide | Compatible | Safe to combine when formula pH is maintained between 5.0 and 6.5. |
| Strong Oxidizing Agents / Heavy Metals | Incompatible | Accelerates degradation and potential discoloration; avoid direct exposure. |
Why Source Ascorbyl Glucoside from UET Chemical
Partnering with UET Chemical gives your manufacturing operations a competitive edge through uncompromised quality assurance and responsive supply chain management.
| Advantage Pillar | UET Chemical Capability & Standard |
| Quality Management | Manufactured under ISO 22716 GMP guidelines with rigorous in-house HPLC assay testing. |
| Regulatory Support | REACH registered profile and complete compliance documentation for global market entry. |
| Supply Consistency | Scalable factory-direct output ensuring stable year-round supply for commercial-scale operations. |
| Flexible Logistics | Low MOQ options: 2.2 lbs (1 kg) trial sample size available; standard 55.1 lbs (25 kg) industrial packaging for bulk orders. |
| Responsive Service | Guaranteed 12-hour response time from our dedicated international technical and commercial desk. |
Ascorbyl Glucoside FAQ
Q1:What is the main difference between Ascorbyl Glucoside and standard L-Ascorbic Acid?
A:Standard L-Ascorbic Acid is highly unstable, prone to rapid oxidation in water, and turns yellow or brown upon exposure to air. Ascorbyl Glucoside features a protective glucose molecule attached to its active site, making it exceptionally stable in aqueous formulations. It releases pure Vitamin C slowly via skin enzymes, offering long-lasting benefits without rapid degradation.
Q2:What is the optimal pH range for formulations containing Ascorbyl Glucoside?
A:The optimal pH range for stability and performance is between 5.0 and 7.0. This neutral-to-slightly-acidic range ensures skin comfort and prevents premature chemical breakdown of the glycoside bond during shelf storage.
Q3:Does Ascorbyl Glucoside require specialized processing equipment during manufacturing?
A:No specialized equipment is required. It is highly water-soluble and can be easily dissolved in the water phase of standard cosmetic manufacturing vessels under normal agitation at moderate temperatures (≤ 122°F / 50°C).
Q4:How is the purity of UET Chemical’s Ascorbyl Glucoside verified?
A:Every production batch is tested in-house using High-Performance Liquid Chromatography (HPLC) to guarantee a minimum purity of 98.0%, supported by full third-party elemental and microbiological profiling.
Q5:What are the standard shipping and delivery timelines for bulk orders?
A:For standard 55.1 lbs (25 kg) fiber drum packages, stock orders typically dispatch within 3 to 5 business days. International shipping timelines vary by destination, with expedited air and ocean freight options available.
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