Ergothioneine (EGT) CAS 497-30-3

Introduction to Ergothioneine

Ergothioneine is a naturally occurring sulfur-containing histidine betaine derivative that accumulates selectively in mammalian cells via specific transporter uptake. It delivers potent, long-lasting antioxidant defense by scavenging reactive oxygen species, chelating redox-active metal ions and protecting cellular structures from oxidative stress. It appears as a white crystalline powder at room temperature, highly soluble in water and stable across a wide pH and temperature range.

Unlike many common antioxidants, EGT is not easily depleted during radical neutralization and maintains activity through repeated redox cycles. It is widely used in premium cosmetics and personal care products for anti-aging, photoprotection and barrier support benefits.

Ergothioneine Chemical & Physical Properties

Applications of Ergothioneine

Anti-aging skincare: Incorporated into serums, creams and eye care products to neutralize free radicals, reduce oxidative stress and improve skin tone and texture. It supports dermal matrix health and diminishes signs of environmental aging.

Photoprotection and repair: Added to sun care and after-sun formulations to mitigate UV-induced cellular damage and photoaging. It protects DNA and membrane lipids from oxidative insult and supports skin recovery after sun exposure.

Hair and scalp care: Formulated into shampoos, conditioners and scalp treatments to protect follicles from oxidative stress and environmental damage. It helps strengthen hair fibers and maintain scalp barrier health.

Nutricosmetic and oral care: Used as a bioactive ingredient in dietary supplements and oral beauty products to support systemic antioxidant defense and maintain tissue health from within.

Storage & Safety Precautions for Ergothioneine

• Store in tightly sealed, light-resistant containers in a cool, dry warehouse below 25 °C. Protect from direct sunlight, high humidity and heat to preserve bioactivity and avoid degradation.
• Wear safety goggles, dust masks and nitrile gloves during bulk powder handling. Avoid dust inhalation and direct contact with eyes and skin.
• Keep separated from strong oxidizing agents and extreme pH conditions. Store away from food and feed materials to prevent cross-contamination.

Ergothioneine FAQ

Q: What core skincare benefits does Ergothioneine (EGT) deliver?

A: It provides potent intracellular antioxidant defense, scavenges free radicals, protects against photoaging and improves skin texture and tone.

Q: How stable is Ergothioneine in cosmetic formulations?

A: It shows excellent thermal and pH stability, is highly water-soluble and retains activity through repeated redox cycles in formulations.

Q: How should Ergothioneine be stored to maintain bioactivity?

A: Store sealed in cool, dark, dry conditions. Protect from light, heat and strong oxidizers to preserve potency.